abstract：:The pyramidal tract of the rat consists of at least two components. A majority of the fibers cross in the lower medulla and descend through the spinal cord in the ventral portion of the dorsal funiculus. The remaining 5% of the corticospinal projection does not cross and descends in the ipsilateral ventral funiculus i...

journal_title：Behavioural brain research

authors： Whishaw IQ,Metz GA

更新日期：2002-08-21 00:00:00

abstract：:The role of the nucleus basalis magnocellularis (NBM) in learning and memory has been demonstrated in different learning paradigms such as conditioned taste aversion (CTA) and inhibitory avoidance (IA). This participation has been related to the cholinergic system, but recent studies have reported the potential role o...

journal_title：Behavioural brain research

authors： Morón I,Ramírez-Lugo L,Ballesteros MA,Gutiérrez R,Miranda MI,Gallo M,Bermúdez-Rattoni F

更新日期：2002-08-21 00:00:00

abstract：:Animal (monkey, rat, mouse) models are widely used to investigate degenerative processes and potential therapeutic treatments for human Parkinson's disease (PD). One task that has proved useful in these investigations is a reach-to-grasp task (skilled reaching) in which an animal reaches for a piece of food that it th...

journal_title：Behavioural brain research

authors： Whishaw IQ,Suchowersky O,Davis L,Sarna J,Metz GA,Pellis SM

更新日期：2002-07-18 00:00:00

abstract：:Learning and memory of early postnatal protein malnourished rats were investigated in the Morris water maze. During the lactation period (21 days) each litter (mother plus six male and two female pups) was provided with 16% (well-nourished) or 6% (malnourished) protein diets. After weaning, rats remained on the same d...

journal_title：Behavioural brain research

authors： Fukuda MT,Françolin-Silva AL,Almeida SS

更新日期：2002-07-18 00:00:00

abstract：:NKP608 is a potent, selective and orally active non-peptidic neurokinin-1 (NK1)-receptor antagonist for which anxiolytic- and antidepressant-like effects have been described in various animal models in rats. Since species differences have been reported for some NK1-receptor antagonists, NKP608 was tested here in the s...

journal_title：Behavioural brain research

authors： Gentsch C,Cutler M,Vassout A,Veenstra S,Brugger F

更新日期：2002-07-18 00:00:00

abstract：:The effect of exogenous melatonin (MEL) on the circadian system in nocturnal species has been extensively studied, but little is known about its chronobiotic effect in diurnal mammals. The present study investigated the effect of exogenous MEL on the circadian locomotor activity rhythm in the diurnal rodent Arvicanthi...

journal_title：Behavioural brain research

authors： Slotten HA,Krekling S,Sicard B,Pévet P

更新日期：2002-06-15 00:00:00

abstract：:The behavioural effects of hippocampal lesions have been extensively documented in rats. However, paradigms developed for rats cannot be assumed to transfer straightforwardly to mice; the behaviour of the two species differs in many respects. Mice are currently the species of choice for targeted genetic manipulations....

journal_title：Behavioural brain research

authors： Deacon RM,Croucher A,Rawlins JN

更新日期：2002-05-14 00:00:00

abstract：:For nonhumans, it has been shown that the hippocampus (HPC) is critical for spatial memory. We tested patients with unilateral HPC resections on a virtual analogue of a classic spatial task to assess HPC functioning in nonhumans: the Morris water task. We found that when humans are required to use spatial cues to navi...

journal_title：Behavioural brain research

authors： Astur RS,Taylor LB,Mamelak AN,Philpott L,Sutherland RJ

更新日期：2002-04-15 00:00:00

abstract：:When exposed to extreme cold or injected with the alpha(2)-adrenoceptor agonist, clonidine, infant rats emit ultrasonic vocalizations (USVs). Based upon the cardiovascular changes that accompany these two manipulations, especially decreased venous return, it was hypothesized that USVs are the acoustic by-product of th...

journal_title：Behavioural brain research

authors： Blumberg MS,Sokoloff G,Kirby RF,Knoot TG,Lewis SJ

更新日期：2002-04-01 00:00:00

abstract：:It has been suggested that delayed (non-) matching to sample (DNMTS/DMTS) tasks using trial-unique stimuli and short, as well as longer delay intervals, can provide important insights into animal cognition. Therefore, this research examined the capability of the New World capuchin monkey (Cebus apella) in perform tria...

journal_title：Behavioural brain research

authors： Tavares MC,Tomaz C

更新日期：2002-04-01 00:00:00

abstract：:In the USA, the stimulant drug methylphenidate (MPH) is used to treat a large number (2 million or more per year) of children with Attention Deficit Hyperactivity Disorder (ADHD). Although the US FDA approved MPH in the 1960s, the pharmacokinetic (PK) properties of serum concentrations of MPH in children with ADHD wer...

journal_title：Behavioural brain research

authors： Swanson JM,Volkow ND

更新日期：2002-03-10 00:00:00

abstract：:In order to assess the role of dopamine (DA) D2 and D3 receptors in the modulation of behaviour, we analysed exploration in a spatial novelty in mouse model systems. Genetically engineered mice mutants have been used that carry normal, partial or no expression of D2R, D3R, or both D2R/D3R (double mutants) DA receptor ...

journal_title：Behavioural brain research

authors： Vallone D,Pignatelli M,Grammatikopoulos G,Ruocco L,Bozzi Y,Westphal H,Borrelli E,Sadile AG

更新日期：2002-03-10 00:00:00

abstract：:The behavioural responses to two commonly used 'predator odours' were assessed in male Wistar rats. Cat odour was presented to rats in the form of a piece of collar that had been worn by a domestic cat. Fox odour was presented in an equivalent piece of (unworn) collar that had been impregnated with 2,4,5 Trimethylthia...

journal_title：Behavioural brain research

authors： McGregor IS,Schrama L,Ambermoon P,Dielenberg RA

更新日期：2002-02-01 00:00:00

abstract：:It has been proposed that long-term potentiation (LTP), a form of activity-dependent modification of synaptic efficacy, may be a synaptic mechanism for certain types of learning. Recent studies on the insular cortex (IC), a region of the temporal cortex implicated in the acquisition and storage of conditioned taste av...

journal_title：Behavioural brain research

authors： Escobar ML,Alcocer I,Bermúdez-Rattoni F

更新日期：2002-02-01 00:00:00

abstract：:We have previously observed that a single exposure to a severe stressor such as immobilization in wooden boards (IMO) resulted in a faster return of plasma corticosterone (and to a lesser extent of ACTH) to basal activity when the rats were exposed again to the same stressor. In addition, the effect enhanced with time...

journal_title：Behavioural brain research

authors： Dal-Zotto S,Martí O,Armario A

更新日期：2002-02-01 00:00:00

abstract：:Despite extensive research on the relationship between acute stress and hippocampal function in adults, little is known about the short- and long-term effects of prolonged juvenile stress on learning, memory, and other hippocampal functions. This experiment investigated whether spatial learning would be altered in juv...

journal_title：Behavioural brain research

authors： Frisone DF,Frye CA,Zimmerberg B

更新日期：2002-01-22 00:00:00

abstract：:We present the case for a model-based approach to the statistical analysis of rodent locomotion data for which previous research has established that the time course of behavioral change follows a specified parametric form. Inadequacies of statistical methods commonly applied to such data are described. Regression mod...

journal_title：Behavioural brain research

authors： Welge JA,Richtand NM

更新日期：2002-01-07 00:00:00

abstract：:One of the routine memory abilities impaired in amnesic patients with temporal-lobe damage is object-recognition memory--the ability to discriminate the familiarity of previously encountered objects. Reproducing this impairment has played a central role in animal models of amnesia during the past two decades, and unti...

journal_title：Behavioural brain research

authors： Mumby DG

更新日期：2001-12-14 00:00:00

abstract：:A peripheral injection of glucose has been found to improve memory in rats, but the underlying mechanisms are unknown. One possible mechanism by which peripheral glucose might act on memory storage is by regulating ATP-sensitive potassium (K-ATP) channels. The present study investigated the effects of K-ATP channel mo...

journal_title：Behavioural brain research

authors： Rashidy-Pour A

更新日期：2001-11-29 00:00:00

abstract：:Young rats become immobile when exposed to a potentially infanticidal adult male rat. Male-induced immobility declines during the preweaning period, paralleling the decrease in infanticidal threat. To investigate the neural substrates underlying the developmental change in immobility, male-induced expression of the im...

journal_title：Behavioural brain research

authors： Wiedenmayer CP,Barr GA

更新日期：2001-11-29 00:00:00

abstract：:Mice altered by transgenesis or gene targeting ("knockouts") have increasingly been employed as alternative effective tools in elucidating the genetic basis of neurophysiology and behavior. Standardization of specific behavioral paradigms and phenotyping strategies will ensure that these behavioral mouse mutants offer...

journal_title：Behavioural brain research

authors： Anagnostopoulos AV,Sharp JJ,Mobraaten LE,Eppig JT,Davisson MT

更新日期：2001-11-01 00:00:00

abstract：:The endogenous circadian clock of mammals retains synchrony with the external light:dark cycle through ocular photoreceptors. To date the identity of the photoreceptors responsible for mediating this response is unknown. This review outlines attempts using transgenic mouse models to address this deficit. Mice bearing ...

journal_title：Behavioural brain research

authors： Lucas RJ,Freedman MS,Lupi D,Munoz M,David-Gray ZK,Foster RG

更新日期：2001-11-01 00:00:00

abstract：:Currently, the behavioural phenotyping of mutant strains is restricted by the paucity of tests for the cognitive capabilities of mice. Most of the paradigms at present available such as the water maze or passive avoidance are dependent upon an aversive component for conditioning and as a consequence the data can often...

journal_title：Behavioural brain research

authors： Marston HM,Spratt C,Kelly JS

更新日期：2001-11-01 00:00:00

abstract：:The dorsal periaqueductal gray matter (DPAG), superior and inferior colliculus have been implicated in the control of defense reactions in the midbrain. Electrical and chemical stimulation of these structures induces escape behavior, usually accompanied by autonomic responses and antinociception. GABA, 5-HT, opioids, ...

journal_title：Behavioural brain research

authors： Santos NR,Huston JP,Brandão ML

更新日期：2001-10-15 00:00:00

abstract：:Retrieval of inhibitory avoidance has been recently shown to require intact glutamate receptors, protein kinases A and C and mitogen-activated protein kinase in the CA1 region of the rat hippocampus and in the entorhinal, posterior parietal and anterior cingulate cortex. These enzymatic activities are known to be modu...

journal_title：Behavioural brain research

authors： Barros DM,Mello e Souza T,De David T,Choi H,Aguzzoli A,Madche C,Ardenghi P,Medina JH,Izquierdo I

更新日期：2001-09-28 00:00:00

abstract：:This paper provides the first report of spatial learning in guinea pigs using the Morris water maze (MWM). Male and female guinea pigs were trained for 5 consecutive days (8 trials/day; acquisition phase) in either the visible (cued) or the hidden (non-cued) platform version of the MWM. In both tests, guinea pigs lear...

journal_title：Behavioural brain research

authors： Dringenberg HC,Richardson DP,Brien JF,Reynolds JN

更新日期：2001-09-28 00:00:00

abstract：:Neonatal exposure to low doses of nicotine has been shown to disturb the development of low-affinity nicotinic binding sites in the cerebral cortex and to elicit a deviant behavioural response to nicotine in adult mice. In this study, 10-day-old male NMRI mice were exposed to one of three different doses of nicotine (...

journal_title：Behavioural brain research

authors： Ankarberg E,Fredriksson A,Eriksson P

更新日期：2001-09-14 00:00:00

abstract：:There are indications of a modulatory role carried out by gonadal hormones and pain in cognitive functions. We have examined this issue in male and female rats by assessing the impact of gonadectomy and persistent pain on the object recognition test. Intact and gonadectomized male and female rats were exposed to an op...

journal_title：Behavioural brain research

authors： Ceccarelli I,Scaramuzzino A,Aloisi AM

更新日期：2001-08-27 00:00:00

abstract：:Diabetes mellitus is associated with disturbances of cognitive functioning. The aim of this study was to examine cognitive functioning in diabetic rats using the 'Can test', a novel spatial/object learning and memory task, without the use of aversive stimuli. Rats were trained to select a single rewarded can from seve...

journal_title：Behavioural brain research

authors： Popoviç M,Biessels GJ,Isaacson RL,Gispen WH

更新日期：2001-08-01 00:00:00

abstract：:Neuroendocrinology of chronic stress seems to be characterized by HPA axis hyperactivity and early childhood stressors have been hypothesized to predispose individuals to adult onset depression by means of dysregulation of the HPA axis. Pivagabine (PVG), a hydrophobic 4-aminobutyric acid derivative, has been used expe...

journal_title：Behavioural brain research

authors： Gerra G,Zaimovic A,Giusti F,Baroni MC,Delsignore R,Raggi MA,Brambilla F

更新日期：2001-07-01 00:00:00

abstract：:In rats, exploratory activity and emotional reactivity towards novel stimuli reflect independent biological functions that are modulated differently by rearing experiences. Environmental enrichment is known to improve performance in exploratory tasks, while having inconsistent effects on emotionality. This study exami...

journal_title：Behavioural brain research

authors： Zimmermann A,Stauffacher M,Langhans W,Würbel H

更新日期：2001-06-01 00:00:00

abstract：:We previously reported that voluntary intake of corn oil in the light box showed place preference in the conditioned place preference (CPP) test in mice. In the present study, we investigated the contribution of opioidergic systems to the corn oil-induced CPP in mice. Acquisition of the place preference by corn oil in...

journal_title：Behavioural brain research

authors： Imaizumi M,Takeda M,Sawano S,Fushiki T

更新日期：2001-06-01 00:00:00

abstract：:Isolation rearing is a developmentally specific non-pharmacological manipulation in rats that produces a deficit in sensorimotor gating, as measured by prepulse inhibition (PPI) of the startle reflex. Previous research has demonstrated that the isolation rearing effect on PPI is sensitive to several factors, including...

journal_title：Behavioural brain research

authors： Krebs-Thomson K,Giracello D,Solis A,Geyer MA

更新日期：2001-05-01 00:00:00

abstract：:Lesions of the hippocampus or the fimbria-fornix produce a pronounced hyperactivity in rats. This effect is thought to be due to the loss of glutamatergic hippocampal inputs to the nucleus accumbens, although the mechanisms involved remain unclear. It has been suggested that the hyperactivity is due to changes in accu...

journal_title：Behavioural brain research

authors： Bannerman DM,Gilmour G,Norman G,Lemaire M,Iversen SD,Rawlins JN

更新日期：2001-04-08 00:00:00

abstract：:The possible effect of different cholecystokinin (CCK) receptor antagonists (MK-329 and L-365260) on the maintenance and reactivation of morphine conditioned place preference (CPP) were investigated in rats, respectively. The results show that the maintenance of morphine CPP could be induced by injection of morphine (...

journal_title：Behavioural brain research

authors： Lu L,Huang M,Ma L,Li J

更新日期：2001-04-08 00:00:00

abstract：:The purpose of the present study was to investigate the effects of sex and estrous cycle on exploratory behavior, as well as the degree to which reliance on environmental cues changes with training. Fischer 344 rats were placed three times in an open field box that contained three objects (two identical bottles and a ...

journal_title：Behavioural brain research

authors： Tropp J,Markus EJ

更新日期：2001-03-15 00:00:00

abstract：:The purpose of this study was to develop a model of unilateral cervical (C4-C5) spinal cord contusion injury in the rat and to characterize the functional and histological consequences following three injury levels using a new weight-drop spinal cord injury device. We evaluated forepaw/forelimb and hindlimb functions ...

journal_title：Behavioural brain research

authors： Soblosky JS,Song JH,Dinh DH

更新日期：2001-02-15 00:00:00

abstract：:In previous studies based on high resolution EEG analyses of the 7 h baseline session of 18 adult male Wistar rats [6,14], we have identified four sleep sequences initiating with slow wave sleep (SS) and terminating with waking (W) or paradoxical sleep (PS). Two of these sequences contained an intervening episode of t...

journal_title：Behavioural brain research

authors： Piscopo S,Mandile P,Montagnese P,Cotugno M,Giuditta A,Vescia S

更新日期：2001-02-15 00:00:00

abstract：:A neural network model of classical conditioning (Schmajuk, Lam, and Gray, J. Exp. Psychol.: Anim. Behav. Process, 22, 1996, 321-349) is applied to the description of the neural substrates of latent inhibition. Experimental data suggest that latent inhibition might be controlled by a circuit that involves the hippocam...

journal_title：Behavioural brain research

authors： Schmajuk NA,Cox L,Gray JA

更新日期：2001-01-29 00:00:00

abstract：:We examined four different learning and memory tasks in rats which had been subjected to left carotid artery ligation followed by 2 h hypoxia (8% oxygen) when they were 7 days old. The examination began on the 4th week after insult and continued to 18 weeks post-insult. Compared with the control group, the hypoxic-isc...

journal_title：Behavioural brain research

authors： Ikeda T,Mishima K,Yoshikawa T,Iwasaki K,Fujiwara M,Xia YX,Ikenoue T

更新日期：2001-01-08 00:00:00